Evaluation of the Effects of Harmine on β-cell Function and Proliferation in Standardized Human Islets Using 3D High-Content Confocal Imaging and Automated Analysis.

Functionally, short-term harmine treatment led to an increase in basal insulin secretion in a loosely dose-dependent manner, with the highest dose of 10 μM inducing near-significant or significant increases in all 3 donors ( Figure 4A ).

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