A randomised trial comparing PBT with TACE showed a trend to improved local control with PBT, with similar survival rates. 59 A recent phase III randomised trial by Kim et al. showed 2-year local progression-free rates for PBT were non-inferior to RFA (92.8% vs. 83.2%). 30 Most of these trials used the passive beam scattering method and hypofractionated protocols (10-20 fractions).
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Stereotactic body radiation therapy for hepatocellular carcinoma: From infancy to ongoing maturity.
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