Distinct Inflammatory Macrophage Populations Sequentially Infiltrate Bone-to-Tendon Interface Tissue After Anterior Cruciate Ligament (ACL) Reconstruction Surgery in Mice.

( 62 ) In Cd9 + Il1b + cells, pseudotime trajectories showed a clear trend along with physical‐time dynamics; Cd9 + cell phenotype evolved to day 7 after ACLR surgery with increased expression of inflammatory genes after surgery, and then returned toward a basal phenotype on POD 14 (Fig.

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Strikingly, CD9+ cluster 0 showed highly significant enrichment of canonical inflammatory nuclear factor κB (NF‐κB) and IFN‐γ pathways typical of “M1” classical inflammatory macrophages (Fig. 2 B ).

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