Single inhaler triple therapy (SITT) in asthma: Systematic review and practice implications.

Indeed, the TRIMARAN‐TRIGGER, 10 IRIDIUM 15 and CAPTAIN 18 studies showed that SITT did improve asthma control but changes failed to reach statistical significance perhaps because improved compliance with the comparator intervention (ICS/LABA) due to a Hawthorne effect. 33 Second, if the target TT is persistent airflow limitation, the studies reviewed above 9 , 10 , 15 , 17 , 18 indicate that SITT consistently improves lung function mo

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