Prevalence and phenotype associations of complement factor I mutations in geographic atrophy.

The difference in mean serum FI concentration between patients expressing a rare CFI gene variant of unknown clinical significance (mean = 10.9 μg/ml; SD = 3.5; n = 6) and those expressing no CFI gene variants did not reach statistical significance ( p = .0691). 3.5 CFI gene variants and association with SNPs at 10 common AMD loci and Haplotypes All patients recruited to this study with GA and a serum FI concentration less than 15.6 μg/ml ( n = 88) underwent DNA sequencing at 10 common AMD loci in addition to the sequencing of the CFI gene.

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