Colon fibroblasts from Pirc rats (F344/NTac-Apc^am1137 ) exhibit a proliferative and inflammatory phenotype that could support early stages of colon carcinogenesis.

Interestingly (Table 1 and Figure 5B ), Vimentin and Acta2 (α‐Sma gene) were strongly downregulated in Pirc normal mucosa compared to wt ( P < .01 and <.001, respectively), as was Fibroblast activating protein ( Fap ) and S100a4 although, in these case, the difference was only nearly significant ( P = .077 and .061, respectively).

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