Barely Significant
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Analysis of high-risk pedigrees identifies 11 candidate variants for Alzheimer's disease.

Alzheimers Dement · 2022 · PMC9291865 · PMID 34151536

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approached significanceno p-value reported
Eleven variants spanning 10 genes were prioritized in external datasets: rs201665195 ( ABCA7 ), and rs28933981 ( TTR ) were previously implicated in AD pathology; rs141402160 ( NOTCH3 ) and rs140914494 ( NOTCH3 ) were previously reported; rs200290640 ( PIDD1 ) and rs199752248 ( PIDD1 ) were present in more than one cousin pair; rs61729902 ( SNAP91 ), rs140129800 ( COX6A2 , AC026471 ), and rs191804178 ( MUC16 ) were not present in a longevity cohort; and rs148294193 ( PELI3 ) and rs147599881 ( FCHO1 ) approached significance from analysis of AD‐related phenotypes.

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