Clinical and molecular predictors of fibrotic progression in essential thrombocythemia: A multicenter study involving 1607 patients.

Am J Hematol · 2021 · PMC9293196 · PMID 34424575

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.0800

boldest claim

The sentences

borderline significancep = 0.07so close (0.05 < p ≤ 0.1)

Multivariable analysis confirmed the independent contribution of JAK2 V617F VAF >35% ( p < 0.01; HR 4.0; 95% CI 1.9–8.2) and presence of CALR type 1/1‐like and MPL mutations ( p = 0.003; HR 2.2; 95% CI 1.3–3.8) in predicting MF progression; these risk factors remained significant when analysis was adjusted for age, sex, or palpable splenomegaly; among the latter, only splenomegaly displayed additional borderline significance ( p = 0.07).

also in 7,017 other papers

showed a trendp = 0.08so close (0.05 < p ≤ 0.1)

Moreover, patients with VAF > 35% showed a trend for reduced overall survival ( p = 0.08; HR 1.5; 95% CI 0.9–2.4) without differences in thrombosis risk ( p = 0.9; HR 0.9; 95% CI 0.5–1.6) and leukemic progression ( p = 0.3; HR 2; 95% CI 0.5–7.7) ( Figure S3 ).

also in 53,322 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.