Limited role of the spleen in a mouse model of trained immunity: Impact on neutrophilia.

The differences in the production of the proinflammatory cytokines TNFα and IL‐6 by splenocytes collected from trained mice and ex vivo stimulated with the TLR2 agonist Pam3Cys did not reach statistical significance when compared to splenocytes isolated from PBS‐treated mice (Fig. 1B ).

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