A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer's disease and gastrointestinal tract disorders.

Commun Biol · 2022 · PMC9293965 · PMID 35851147

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For example, of the total 144 SNP subsets tested with AD as data set 1 (Table 3 ), all 144 (for GERD, PGM and gastritis-duodenitis), 139 (PUD), 133 (IBS), 130 (diverticulosis) and 42 (IBD) produced Fisher’s exact tests with at least nominally significant effect concordance (odds ratio [OR] > 1 and P < 0.05).

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