Epigenetic Mechanism of Early Life Stress-Induced Depression: Focus on the Neurotransmitter Systems.

Front Cell Dev Biol · 2022 · PMC9294154 · PMID 35865627

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In the ventral hippocampus of SERT −/− rats at the third week of life, SERT deficiency resulted in a significant decrease in γ2 subunit of GABA A receptor ( GABA A γ2 ) and glutamic acid decarboxylase 1 ( Gad67 ) mRNA levels, while vesicular-GABA transporter ( Vgat ) only showed a trend of decreasing but not statistically significant.

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