Effect of menopausal hormone therapy on methylation levels in early and late postmenopausal women.

Nominally significant ( p < 0.05) associations between methylation levels and smoking were also observed at three of the four other selected smoking-associated CpG sites at baseline and 36 months after treatment, although only cg19859270 and cg03636183 are considered significant at a Bonferroni threshold for testing five CpGs ( p = 0.05/5 = 0.01; Table 2 ).

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A longitudinal EWAS analysis among a subset of ELITE participants with the lowest and highest 36-month CIMT progression identified two CpG sites on chromosomes 12 and 19 that exhibited highly significant interactions between methylation levels, time-since-menopause, and HT.

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