A single local delivery of paclitaxel and nucleic acids via an immunoactive polymer eliminates tumors and induces antitumor immunity.

Proc Natl Acad Sci U S A · 2022 · PMC9295735 · PMID 35609195

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showed a trendno p-value reported

Both tumor cells and immune cells, including macrophages and MDSCs, showed a trend of increased PD-L1 expression, which suggests negative feedback to 2E′/PTX-mediated immunostimulation.

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