The Damage of the Crayfish (<i>Procambarus Clarkii</i>) Digestive Organs Caused by <i>Citrobacter Freundii</i> Is Associated With the Disturbance of Intestinal Microbiota and Disruption of Intestinal-Liver Axis Homeostasis.

Histopathological scores showed that hepatopancreatic cell necrosis, tubule lumen dilatation and vacuolization were the most obvious and common pathological changes in infected crayfish, with highly significant differences in scores between the control and infected groups ( Figure 5C ).

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The analysis showed that the relative abundance of more bacteria in the intestine of crayfish showed a trend of reduction after C. freundii infection ( Figure 1B ).

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