The impact of catch-up bivalent human papillomavirus vaccination on cervical screening outcomes: an observational study from the English HPV primary screening pilot.

Although the unadjusted observed detection of cervical cancer at screening decreased by about 75% between 2013 and 2018 (from >0.1% to <0.05%), the trend did not reach statistical significance.

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The observed reductions in the number of women referred for colposcopy, and in the PPV of those colposcopies, will represent a highly significant change for colposcopy services as nearly half of all colposcopies in the CSP used to be performed in women under 30 years of age [ 8 ].

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