Edoxaban Exposure in Patients With Atrial Fibrillation and Estimated Creatinine Clearance Exceeding 100 mL/min.

In ENGAGE AF‐TIMI 48, patients with CrCL >95 mL/min showed a trend toward decreased efficacy relative to warfarin and had lower edoxaban trough concentrations relative to patients with lower CrCL. 6 Of note, the demographics of patients with high CrCL (>95 mL/min) in ENGAGE AF‐TIMI 48 were similar to the patients enrolled in this study (Table S3 ). 6 Although the current study was not designed to compare clinical events between the 2 treatment arms with sufficient power, the total number of patients with clinical outcome events (stroke or bleeding) was low overall and similar between the 2 treatment arms.

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