Is TIMP-1 a biomarker for periodontal disease? A systematic review and meta-analysis.

J Periodontal Res · 2022 · PMC9299605 · PMID 34850390

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did not reach statistical significanceno p-value reported

This is reflected in the outcome of the meta‐analysis which showed that the difference in TIMP‐1 concentration between healthy participants and patients with gingivitis or periodontitis did not reach statistical significance, and the heterogeneity between the studies was relatively high (Figure 2A‐C ).

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