Scaling-up a fragment-based protein-protein interaction method using a human reference interaction set.

Although the ORF filtering is essential to reduce the screening area when screening large protein pools (unpublished data), there may be significant value in terms of interaction resolution in generating protein fragment libraries that have not been subjected to ORF filtering offer a higher depth of fragment coverage.

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As mentioned above, there was a clear trend for detecting interactions where one of the interacting partners was >350 amino acids.

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