Consistently, in an orthotopic liver injection model in immunodeficient nude, RalGAPA2 KO cells also showed a trend of forming larger liver tumors and having a higher rate of distant pulmonary metastasis (100% vs. 40% in the control group) (Figure S3F ).
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Dysregulation of RalA signaling through dual regulatory mechanisms exerts its oncogenic functions in hepatocellular carcinoma.
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