Short LNA-modified oligonucleotide probes as efficient disruptors of DNA G-quadruplexes.

Nucleic Acids Res · 2022 · PMC9303293 · PMID 35801856

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a clear trendno p-value reported

A clear trend that emerges from this initial screening is that LNA modifications, particularly when placed complementary to the guanines involved in G-tetrad formation, can significantly accelerate the rate of c-KIT1 G4-disruption.

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