Functional variants in cytochrome b5 type A (CYB5A) are enriched in Southwest American Indian individuals and associate with obesity.

It should be noted that although the obesity‐risk haplotype ATA did not reach statistical significance in its association with 24‐h EE, it was directionally consistent (carriers of the high BMI haplotype had lower 24‐h EE; β = −25.0; p = 0.09) and the lack of significance could be due to low power, as the sample size for this phenotype was small.

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