Model to predict on-treatment restoration of functional HBV-specific CD8⁺ cell response foresees off-treatment HBV control in eAg-negative chronic hepatitis B.

25 According to these authors when a statistically significant association is found in a model with ≥5 events per variable (EPV), only a minor degree of caution should be taken to interpret the results, in particular for plausible and highly significant associations hypothesised a priori as it occurs in our study.

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In the cases with expanding CD8 + cells after 10‐day HBVcore 18‐27 in vitro challenge, the percentage of IFN‐γ‐secreting cells was slightly higher in the cohort with a probability of ≥0.5 but it did not reach statistical significance.

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