OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy.

Although these trends may not be significant on an hourly basis, are they significant over 6-h or 12-h periods?

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REM sleep was also suppressed, but did not reach statistical significance because there are few, if any, REM sleep episodes in the first few hours of injection ( S1D Fig ).

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