At 3 months AGI, it was however lower in Pten/Hif1a (i)pe−/− mice than in Pten (i)pe−/− ones, although the reduction did not reach statistical significance ( Fig. 2A ).
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Hypoxia-mediated stabilization of HIF1A in prostatic intraepithelial neoplasia promotes cell plasticity and malignant progression.
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