The Impact of Catalpol on Proliferation, Apoptosis, Migration, and Oxidative Stress of Lung Cancer Cells Based on Nrf2/ARE Signaling.

Activation of Nrf2/ARE Signaling Reverses the Effect of Catalpol on the Proliferation, Apoptosis, and Migration of Lung Cancer Cells Lung cancer cell proliferation activity, migration number, and protein levels of Nrf2, HO-1, MMP-9, and MMP-2 exhibited a declining trend, whereas both protein expressions of Cleaved Caspase-3 and the apoptosis rate showed an increasing trend ( P < 0.05).

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Catalpol Inhibits Nrf2/ARE Signaling in Lung Cancer Cells When compared to the control group, the protein expression levels of Nrf2 and HO-1 in lung cancer cells in the catalpol-12 g/mL group, catalpol-24 g/mL group, and catalpol-48 g/mL group exhibited a negative trend ( P < 0.05) ( Figure 2 ). 3.3.

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