Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations.

In order to identify novel associated loci, we considered the following steps (Figure 2 ): (1) we identified all loci that were statistically significant in the multi‐phenotype analysis ( p ‐value multivariate <1.85 x 10 −9 ) (significant loci); (2) among these, we identified all loci with a lead variant that was at least nominally significant for two of the individual datasets used in each combination of phenotypes (lead variant p ‐value univariate <.005) 30 , 31 , 32 (significant loci driven by more than one phenotype); (3) among the loci from step 2, we then narrowed it down to loci that were new for at least one of the ph

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