A Circulating Risk Score, Based on Combined Expression of Exo-miR-130a-3p and Fibrinopeptide A, as Predictive Biomarker of Relapse in Resectable Non-Small Cell Lung Cancer Patients.

Exo-miR-17-5p alone showed a slightly significant positive association with DFS by microarray data (HR = 1.253, p -value = 0.023, n = 67) but it was not associated with DFS by ddPCR data (HR = 1.028, p -value = 0.623, n = 63); however, when combined in a multivariable model, the HR of Exo-miR-17-5p became lower than “one” (i.e., negatively associated with DFS) and significant, underlying an interaction with miR-130a-3p that seems to balance its positive contribution to the final predictive score.

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