Analysis of Peripheral Blood Basophils in Pediatric Systemic Lupus Erythematosus.

Notably, the number of circulating basophils in pSLE patients (0.20 ± 0.18%) was much lower than in children with JIA (0.43 ± 0.17%) or in those affected with non-rheumatic conditions (NR: 0.48 ± 0.20%); indeed, this difference among these groups was highly significant after statistical analysis ( p = 0.0003).

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Notably, we observed a mildly significant difference in basophil percentage between pSLE patients with mild–moderate disease activity and those with high or very high disease activity based on SLEDAI (0.28 ± 0.19% vs. 0.11 ± 0.11%, respectively; p = 0.0451), as shown in Figure 3 B; a similar finding was not evident for JIA patients, based on JADAS-27 ( Figure 3 C).

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