Compared with the previous findings of CYP2C19 genetic variability and switching, a study among adults [ 4 ] found a more than 3-fold increased frequency of switching within one year in CYP2C19 PM and RM/UM status who were using escitalopram compared with the none finding among PM in adults who were using (es)citalopram and the borderline non-significant association in the RM and UM adults in our study.
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Clinical Impact of Functional CYP2C19 and CYP2D6 Gene Variants on Treatment with Antidepressants in Young People with Depression: A Danish Cohort Study.
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