Multi-Level Biological Network Analysis and Drug Repurposing Based on Leukocyte Transcriptomics in Severe COVID-19: In Silico Systems Biology to Precision Medicine.

The survival analysis using GEPIA2 based on the LAML model in the TCGA database of the 27 hub and bottleneck genes revealed that only MYBL2 provided significant overall survival (log-rank p -value < 0.05) and a high hazard ratio (HR = 1.7); however, there were three genes that were nearly significant overall survival and high hazard ratio, for example, CDC25A (log-rank p -value = 0.064 and HR = 1.7), GUSB (log-rank p -value = 0.057 and HR = 0.58), and SDAD1 (log-rank p -value = 0.082 and HR = 1.6).

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