In Prostate Cancer Cells Cytokines Are Early Responders to Gravitational Changes Occurring in Parabolic Flights.

However, TUBB qPCR results cannot be confirmed by RNAseq results, but TUBB is in RNAseq nominally significant between 1P and 31P ( p = 0.009).

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Notably, seven of the eleven genes mentioned by de Jesús and Ramakrishnan as c-REL knock-out-dependently upregulated [ 30 ] are also highly significant and more than two-fold upregulated after P1 in our PC-3 PF ( Figure 5 ): CCL2 (P adj to 1 g = 5.0 × 10 −49 ), CXCL1 (P adj to 1 g = 2.8 × 10 −50 ), TNFAIP3 (P adj to 1 g = 9.5 × 10 −23 ), IL6 (P adj to 1 g = 4.0 × 10 −6 ), CXCL2 (P adj to 1 g = 5.2 × 10 −33 ), CCL20 (P adj to 1 g = 3.1 × 10 −17 ), and ICAM1 (P adj to 1 g = 1.7 × 10 −52 ), whereas the joint significant upregulation of CCL2 and RELB after the first parabola is in concordance with the CCL2 expression depletion described by de Jesús and Ramakrishnan in the RELB MEF knock out experiment [ 30 ].

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