Following first plasmid challenge, groups of mice treated with N1810Q and N2118Q showed a trend of decreased inhibitor responses to FVIII compared with mice treated with WT BDD-FVIII plasmid, whereas no significant difference in inhibitor responses was observed among N41Q, N239Q, and WT BDD-FVIII plasmid-treated mice.
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Influence of N-glycosylation in the A and C domains on the immunogenicity of factor VIII.
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