Increasing nitric oxide bioavailability fails to improve collateral vessel formation in humanized sickle cell mice.

Lab Invest · 2022 · PMC9329194 · PMID 35354915

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a strong trendno p-value reported

L-Arginine supplementation We found that in the Townes humanized SCD mouse, there was a strong trend for L-arginine treatment to increase circulating arginine, but not NOx levels, despite this treatment successfully enhancing NOx levels in littermate controls.

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