Genome-Wide Association Study of COVID-19 Outcomes Reveals Novel Host Genetic Risk Loci in the Serbian Population.

Front Genet · 2022 · PMC9329799 · PMID 35910207

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0748

boldest claim

The sentences

highly significantp = 3.85 × 10 −46actually significant

According to GeneAtlas, FYCO1 variant rs33910087 is a highly significant modifier of monocyte percentage ( p = 3.85 × 10 −46 ), and based on GTEx v8, this variant is also an eQTL for several protein-coding genes previously associated with COVID-19 ( CXCR6 , FYCO1 , SLC6A20 , CCR1 , LZTFL1 ).

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nominally significantp < 0.05actually significant

We considered an association validated if at least a nominally significant result ( p < 0.05) in the UK biobank was noted in the same direction of association.

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a statistical trendp = 0.0748so close (0.05 < p ≤ 0.1)

2) Variant rs73060324 at 3p21.31 suggestively significant in our GWAS ( p = 7.54 × 10 −6 ) showed a statistical trend related to UK biobank hospitalized positive versus non-hospitalized positive phenotype ( p = 0.0748). 3) Variant rs78317595 at 5q11.2 suggestively significant in our GWAS (p = 6.59 × 10 −6 ) was nominally significant in the UK biobank severe versus non-severe comparison ( p = 0.042).

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