The number of memory lymphocytes was increased in all subgroups of patients, except for dying patients that showed a decreasing trend (mild: basal median 477 (range 192–718), 1 week median 618 (range 425–806) p < 0.001; moderate: basal median 354 (range 202–564), 1 week median 474 (range 346–651) p < 0.0001; severe: basal median 350 (range 214–509), 1 week median 534 (range 306–767) p = 0.02; died: basal median 333 (range 161–683), 1 week median 281 (range 130–534).
Figure 4 shows that in 6/8 patients the number of total leukocytes was increased after one week of hospitalization while, in 5/8 the number of T lymphocytes, T helper, T cytotoxic, T regulatory, and NK lymphocytes, showed a trend of reduction after one week of hospitalization.
The neutrophil/lymphocyte ratio (NLR) was significantly reduced in mild and moderate patients (mild: basal median 6.3 (range 3.8–10), 1 week median 3 (range 1.7–4) p < 0.023; moderate: basal median 6.9 (range 3.5–9.7), 1 week median 4.3 (range 2.5–6.6) p < 0.001), while it showed an increasing trend in patients who died (died: basal median 4.3 (range 2.8–12), 1 week median 8.8 (range 5.1–20) p = ns).