Molecular mechanisms of acquired antifungal drug resistance in principal fungal pathogens and EUCAST guidance for their laboratory detection and clinical implications.

Finally, a significant trend towards decreased voriconazole resistance was noted in TR 34 /L98H isolates in the above-mentioned resistance survey. 49 In 2013 96% (44 of 46) of TR 34 /L98H isolates were classified as voriconazole resistant, while in 2018 only 55% (59 of 108) of TR 34 /L98H isolates exhibited a voriconazole-resistant phenotype ( P = 0.0001). 49 However, no underlying mechanism was found that could explain the voriconazole phenotype shift.

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