Proteome Informatics in Tibetan Sheep (<i>Ovis aries</i>) Testes Suggest the Crucial Proteins Related to Development and Functionality.

Cluster 4 had 2,383 proteins correspond to 1,296 genes, and their expression levels exhibited first a decreasing trend and then increase with age ( Figure 1C ).

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Of these proteins, 11 proteins (i.e., DLD, GPX4, HSPA2, ODF2, PGAM2, PGK2, PIN1, RDH11, ROPN1L, SEC23IP, and ZPBP) showed a trend of increasing first and then decreasing, four proteins (i.e., ARPC5, CLIC4, CTNNB1, and LMNA) showed a clear pattern of decreasing expression, and the remaining three proteins (i.e., ASF1B, RBMXL2, and TDRD6) were upregulated ( Figure 4 ).

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p -values of < 0.05 and < 0.01 were considered significant and extremely significant, respectively.

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