There was a significant trend among quartiles of serum tHcy levels and risk of the severity of different imaging markers of CSVD, except for CSO-EPVS after controlling for age, sex, education, current smoking, alcohol use, hypertension, diabetes, history of stroke, LDL-C, and HDL-C ( Table 3 ).
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Cerebral small vessel disease mediates the association between homocysteine and cognitive function.
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