Safety, Tolerability, Pharmacokinetics and Initial Pharmacodynamics of a Subcommissural Organ-Spondin-Derived Peptide: A Randomized, Placebo-Controlled, Double-Blind, Single Ascending Dose First-in-Human Study.

For the post hoc analyses, the EEG activity (with all doses combined) after a single intravenous administration of NX210 over time showed a trend for increasing variation in the alpha power bands ( p = 0.84), with a maximum observed at 40 min (17.5% [SE = 16.9]); this variation was sustained at 24 h and 48 h (14.3% [SE = 19.5] and 13.2% [SE = 13.1], respectively) (Fig. 5 ).

also in 53,322 other papers

Urinary Biomarkers For the dose of 10 mg/kg, the mean percentage changes from baseline over time showed an increasing trend in the urinary excretion of serotonin at 70 min and 48 h (mean = 55.2% [SE = 33.0] and 19.0% [18.9], respectively (Fig. 3 ); glutamate at 10 h (mean = 57.5% [SE = 37.3]); and GABA at 10 and 48 h (mean = 74.7% [SE = 45.1] and 30.0% [SE = 19.9], respectively (data not shown).

also in 63,971 other papers