A Narrative Review on Axonal Neuroprotection in Multiple Sclerosis.

Neurol Ther · 2022 · PMC9338208 · PMID 35610531

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did not reach statistical significanceno p-value reported

( NCT00950248 ), idebenone was well tolerated but the change the area under the curve of the Combinatorial Weight-Adjusted Disability Score (CombiWISE) between idebenone and placebo did not reach statistical significance, attesting that idebenone does not inhibit disability progression in PPMS [ 348 ].

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