marginally significantp = 0.068
On the other hand, reduced risk of death was seen in patients with any reduction in tumor AEF (decrease ratio ≥ 0) and with increased AEF but not exceeding the ratio of 0.102 (increase ratio < 0.102) (HR = 0.32, p < 0.001), though the protective effect was marginally significant in the multivariate analysis (HR = 0.61, p = 0.068).