Treatment of diabetic macular edema in real-world clinical practice: The effect of aging.

However, although a certain degree of CRT improvement was obtained in each age category, the overall mean CRT at 2 years (335.7 μm) was much higher than that in previous RCTs (<300 μm in most RCTs and <200 μm in the RIDE trial) 5 , 6 , 7 , 8 , and a significant trend was observed that the mean decrement in CRT is lower with increasing age group.

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There were several significant differences in age categories: a decreasing trend of male predominance and serum HbA1c and eGFR levels and an increasing trend of the duration of diabetes as age category advances.

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