Micro-RNA-215 and -375 regulate thymidylate synthase protein expression in pleural mesothelioma and mediate epithelial to mesenchymal transition.

Finally, we found a borderline significance ( p = 0.05) for survival analysis in those cases with different TS protein levels, while we failed to found significant survival differences either for miRNA expression, or for EMT morphology.

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A little significant difference was found in survival curves between cases with low and high TS protein expression: lower levels of TS protein give a slightly better survival as compared to higher levels (12 vs. 8.5 months, log-rank p = 0.05).

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Only the t-REN, epithelioid PM cell line, showed a trend to a higher sensitivity to PEM, as compared to untreated t-REN cells, after 72 h of PEM treatment, although not reaching statistical significance.

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