Evaluation of rapid transepithelial electrical resistance (TEER) measurement as a metric of kidney toxicity in a high-throughput microfluidic culture system.

Barrier function of co-cultures exposed to 15 μM cisplatin showed a decreasing trend but was only reduced to a significant degree under low FSS after 72 h.

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Consistent with the level of differentiation suggested by their morphology, hRPTEC tended to be less metabolically active in mono-culture than in co-culture, although this trend did not reach statistical significance (Fig. 2 b). hRPTEC also tended to be more proliferative, based on Ki67 staining, on day nine in mono-culture, a trend that was statistically significant under high FSS (Fig. 2 c, representative images in Supplementary Fig.

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