Type 2 diabetes disrupts circadian orchestration of lipid metabolism and membrane fluidity in human pancreatic islets.

PLoS Biol · 2022 · PMC9348689 · PMID 35921354

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highly significantno p-value reported

In contrast, this difference was highly significant for PUFA 3, even after deisotoping correction of the lipid signals ( Fig 2P and 2Q ).

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an overall trendno p-value reported

Our lipidomic analysis revealed an overall trend for lowering PE species, with the levels of PE-PUFAs being significantly decreased in islets from T2D patients as compared to their ND counterparts (Figs 2P and 2Q and 3M and 3N ).

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did not reach statistical significanceno p-value reported

Overall, we observed a concomitant trend of decreased PE lipid levels and increased PC levels in the T2D islet group, resulting in a trend toward an increase PC/PE ratio that did not reach statistical significance ( Fig 2C and 2D ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.