The inositol 5-phosphatase INPP5B regulates B cell receptor clustering and signaling.

Using MS to measure the total mass of cellular PIP2 (which will be mostly PI(4,5)P 2 ; Clark et al., 2011 ) indicated a slight increase in INPP5B-depleted cells stimulated with anti-IgM in solution, although the difference did not reach statistical significance ( Fig.

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