CD4+ T-Cell Epitope Prediction by Combined Analysis of Antigen Conformational Flexibility and Peptide-MHCII Binding Affinity.

For data from human subjects, we found a similar trend, with PPVs of 29%, 30%, 31%, 37%, and 43% at the 80th, 83rd, 90th, 91st, and 95th percentile thresholds, respectively. This shows a clear trend of more accurate predictions with more stringent thresholds, primarily due to reductions in the numbers of false positives.

also in 19,460 other papers