Contribution of HIF-P4H isoenzyme inhibition to metabolism indicates major beneficial effects being conveyed by HIF-P4H-2 antagonism.

The histologically analyzed adipocyte size did not differ between the aged Hif-p4h-1 KO or Hif-p4h-3 KO mice and WT, respectively, but there was an almost significant reduction in the number of macrophage aggregates in the Hif-p4h-1 KO WAT and a significant increase in the Hif-p4h-3 KO WAT ( Figs. 1, I – L and S2 ).

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There were also reductions of about 25% and 15% in the WAT and liver weights of the FG-4539-treated mice, respectively, although the 60-mg/kg dosage did not reach statistical significance ( Fig. 3 , D and E ).

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