Barely Significant
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London parochial burial records from 1563 to 1665 indicate higher plague death rates for males than females: Some possible demographic and social explanations.

PLoS One · 2022 · PMC9355180 · PMID 35930534

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highly significantno p-value reported
In actual fact 1603 was a highly significant year politically, for it marked the death of Queen Elizabeth I and the accession of James I (James VI of Scotland) together with the union of the English and Scottish Crowns on the 24 th March. 1625 was also politically significant for it marked the death of James I and the accession of Charles I.

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The sex ratio remained relatively constant except for a decrease in 1665 but this apparent difference did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.