Endoplasmic reticulum stress triggered autophagy and regulated the phenotype transformation of rheumatoid arthritis synovial fibroblasts via the IRE1/JNK pathway.

Ann Transl Med · 2022 · PMC9358491 · PMID 35957705

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IRE1 knockdown also showed a strong trend toward decreased expression of GRP78, PERK and LC3, but did not significantly downregulate the expression of ATF6 ( Figure 5A ).

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